Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling

Inositol phosphatesare widely produced in animal and plant tissues. Luo and colleagues demonstrate that the inositol phosphateInsP7 modulates membrane translocation of the kinase Akt and downstream phosphatidylinositol-( 3,4,5)- trisphosphatesignaling in neutrophils.