A novel principled method for the measurement of vascular robustness uncovers hidden risk for premature CVD death

The detection of high risk for premature death of cardiovascular disease (CVD) among individuals with low-to-moderate risk factorscores is a major challenge. Systems biologysuggests that the vasculature's functional robustness against risk factorchallenges may serve as a novel discriminator of mortality risk under similar risk factorloads. However, principled methods to measure vascular robustness are not available. To develop a score for the vasculature's functional robustness we used a recently presented method that applies computational physiological modeling to the quantitation of vascular function. We hypothesized that the expected inverse robustness-mortality association is verifiable as a significant robustness-calendar age trend in a cross-sectional investigation of a population cohort of risk factor-challenged individuals. Using only functional parameters of the cardiovascular system we applied multivariate linear regression to derive from our study population of 372 adults gender-specific mu...