Direct Interactions With Cancer-Associated Fibroblasts Lead to Enhanced Pancreatic Cancer Stem Cell Function

ObjectiveCancer-associated fibroblasts (CAFs) play an important role in the progression of pancreatic ductal adenocarcinoma (PDAC) by promoting tumor cell migrationand drug resistance. We determined the impact of CAFs on PDAC cancer stem cells(CSCs).MethodsFibroblast cell lines from patients' tumo