PID1 in adipocytes modulates whole-body glucose homeostasis
2018
Abstract The novel obesity-associated protein P hosphotyrosine I nteraction D omain containing 1 (PID1) inhibits insulin-PI3K/Akt signaling pathway and insulin-stimulated
glucose uptakein vitro . In this study, we generated fat tissue-specific aP2-PID1 transgenic (aP2-PID1 tg ) mice and PID1 knockout (PID1 −/− ) mice to explore how PID1 affects glucose metabolism in vivo . We observed insulin resistance and impaired insulin-PI3K/Akt signaling in aP2-PID1 tg mice. Consistent with these data, the PID1 −/− mice displayed improved glucose tolerance and insulin sensitivity under chow diet, with increased Akt phosphorylation in
white adipose tissue(WAT). We further demonstrated that PID1 could interact with low density
lipoprotein receptor-related protein1 (
LRP1) but not the
insulin receptor(IR) in adipocytes, and its overexpression could lead to decreased
GLUT4level. Our results thus indentify PID1 as a critical regulator of glucose metabolism in adipocytes.
Keywords:
-
Correction
-
Source
-
Cite
-
Save
16
References
7
Citations
NaN
KQI