small interfering (siRNA) for oral administration ribonucleic acid

The small interfering ribonucleic acid (siRNA) covered 3 'hydroxypropoxy phosphodiester, said ARNipque comprises two RNA strands separate that are complementary over at least 19 nucleotides, wherein each strand is 49 nucleotides or less, and wherein the first two base pairing in elnucleotido at the 3 'end of each strand are 2'-methoxyethyl ribonucleotide residues.