Therapeutic Management of Pyriform Sinus Cancer: Results of a Single-Center Study of 122 Patients

ObjectiveTo analyze the survival rateof a nonselected pyriform sinus cancer population.Study DesignCase series with chart review.SettingUniversity hospital.Subjects and MethodsA total of 122 patients were included in this study covering the 2002-2008 period. All patients had squamous cellcarcinoma originatingfrom the pyriform sinus. Survivaland prognostic factors were analyzed.ResultsThe 3- and 5-year overall survival rateswere 39.7% and 2.4%, respectively. The 3- and 5-year survival rateswithout recurrence were 34% and 27%, respectively. The median survival ratesby UICC stage were as follows: stage 1 and 2 patients, 60 months; stage 3, 40 months; stage 4, 19 months. Stage 4 patients had a lower median survival ratethan other stages (P = .039). The 5-year survival ratewas 46% for patients having T3-T4 operable cancers treated by surgery vs 45% for patients treated by laryngeal conservation protocol (not significant). The 5-year survival ratefor patients having nonoperable T4 cancers was 17.2%. T...