Enhanced whole exome sequencing by higher DNA insert lengths
2016
Background Whole
exome sequencing(WES) has been proven to serve as a valuable basis for various applications such as variant calling and
copy number variation(CNV) analyses. For those analyses the read coverage should be optimally balanced throughout protein
coding regionsat sufficient read depth. Unfortunately, WES is known for its uneven coverage within
coding regionsdue to GC-rich regions or off-target enrichment.
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