Association between Carotid Artery Stenosis and Cognitive Impairment in Stroke Patients: A Cross-Sectional Study.
2016
To investigate potential associations between carotid artery
stenosisand cognitive impairment among patients with acute ischemic stroke and to provide important clinical implications. We measured the degree of carotid artery
stenosisand recorded the
Mini-Mental State Examinationscore (MMSE) at admission in 3116 acute ischemic stroke patients. The association between carotid
stenosisand cognitive impairment assessed by MMSE was tested using multivariate regression analysis. Other clinical variables of interest were also studied. After adjusting for age, gender, education level, marriage, alcohol use, tobacco use, physical activity, hypertension, diabetes, hypercholesterolemia, atrial fibrillation, myocardial infarction and NIHSS (National Institutes of Health Stroke Scale) score, we found that participants with high-grade
stenosisof the carotid artery had a higher likelihood of cognitive impairment compared to those without carotid artery
stenosis(OR = 1.49, 95%CI: 1.05–2.11, p<0.001). Left
common carotid artery
stenosiswas associated with cognitive impairment in the
univariate analysis, although this effect did not persist after adjustment for the NIHSS score. Cognitive impairment was associated with high-grade
stenosisof the right carotid artery.
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