Short- and long-term outcomes of endoscopic resection of rectal neuroendocrine tumours: analyses according to the WHO 2010 classification

AbstractObjective Although the World Health Organisation (WHO) defined a novel classification of gastroenteropancreatic neuroendocrine tumours ( NETs) in 2010, indications for endoscopic resectionof rectal NETsin the guidelines were based on evidence accumulated for carcinoid tumoursdefined by a previous classification. This study was designed to clarify indications for endoscopic resectionof rectal NETscorresponding to the new WHO classifications. Material and methods One hundred-seventy rectal NETs resected endoscopicallyfrom April 2001 to March 2012 were histologically re-classified according to the WHO 2010 criteria. The clinicopathological features of these lesions were analysed, and the short- and long-term outcomes of endoscopic resectionwere evaluated. Results Of the 170 rectal NETs, 166 were histopathologically diagnosed as NETG1 and four as NETG2. Thirty-eight tumours (22.4%) were positive for lymphovascular invasion, a percentage higher than expected. Although the curative resectionrat...