Renal Targeting: Peptide-Based Drug Delivery to Proximal Tubule Cells.
2016
Kidney-specific drug targeting is an attractive strategy to reduce unwanted side effects and to enhance drug efficacy within the renal tissue. For this purpose a novel kidney-specific
drug carrierwas developed. The
peptide sequence(KKEEE)3K triggers exceptional renal specificity at high accumulation rates. Micro-PET imaging studies of megalin-deficient mice indicate that the cellular endocytosis of this carrier is mediated by megalin. This assumption is supported by immunohistochemical analysis of FITC-labeled carrier peptide, which exclusively accumulated at the apical side of
proximal tubulecells within the
renal cortex. Scintigraphic studies of modified
ciprofloxacinconjugated to (KKEEE)3K confirmed the excellent drug targeting potential of the peptide carrier. The conjugate accumulated entirely in the kidneys, revealing flawless redirection of
ciprofloxacin, a compound that is mainly excreted by the liver. In conclusion, these results suggest the potential of (KKEEE)3K as a promising candidate for...
Keywords:
-
Correction
-
Source
-
Cite
-
Save
35
References
36
Citations
NaN
KQI