Serum concentrations of clarithromycin and rifampicin in pulmonary Mycobacterium avium complex disease: long-term changes due to drug interactions and their association with clinical outcomes.
2015
Background Concomitant use of
clarithromycin(CAM) and
rifampicin(RFP) for the treatment of pulmonary
Mycobacterium avium complex(MAC) disease affects the systemic concentrations of both drugs due to
CYP3A4–related interactions. To date, however, there has been no report that investigates the long–term relationship between the drug concentrations,
CYP3A4activity, and clinical outcomes. Our aim was to investigate the time course of the drug levels in long–term treatment of subjects with pulmonary MAC disease, and examine the correlation of these concentrations with
CYP3A4activity and clinical outcomes.
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