Serum myeloperoxidase (MPO) activity, oxidative and antioxidative parameters in operating room personnel.

To investigate the effects of occupational exposure to anaesthetic gases on myeloperoxidaseactivity, oxidative and antioxidative parameters in operating roompersonnel.The cross-sectional study was conducted at Yuzuncu Yil University, Van, Turkey, in May 2011, and comprised equal number of operating roomand non-operating roompersonnel. Serum myeloperoxidaseactivity, sulfhydryl group levels, lipid hydroperoxide levels and catalaseactivity were determined. SPSS 11 was used for data analysis.There were 64 subjects; 32(50%) each in the two groups. Myeloperoxidaseactivity and lipid hydroperoxide levels were significantly higher in operating roompersonnel than in the non-operating roompersonnel (p<0.001; p<0.001), while catalaseactivity and sulfhydryl group levels were significantly lower (p<0.009; p<0.003). Catalaseactivity negatively correlated with lipid hydroperoxide levels in operating roompersonnel (r=-0.293; p=0.018). Myeloperoxidaseactivity negatively correlated with sulfhydryl group levels in operating roompersonnel (r=-0.267; p=0.031).Operating roompersonnel exhibited higher oxidative stress, which may be due to the oxidative effect of anaesthetic gases.