The Effects in Myometrial Preparations of D2343, a β2-Adrenoceptor Agonist Possessing α1-Receptor Blocking Qualities

: D2343 is a compound with about the same β2-adrenoceptor-agonistic effect as terbutaline and exhibiting in addition an α1-receptor inhibitory activity. D2343 has been compared to the β2-agonist terbutaline on oestrogenized uterine preparations from rat and rabbit (in vitro and in vivo) and in myometrial strips from homo. Generally, D2343 has shown an ability to relax the uterine muscles to the same degree as terbutaline or even more, especially when the two drugs were compared in vitro in preparations from rabbit and rat.