Temperature selection in antegrade cerebral perfusion for aortic arch surgery: a meta-analysis

Abstract Background The increasing use of antegrade cerebral perfusion (ACP) during aortic arch surgery has corresponded with a trend towards warmer target temperatures for hypothermic circulatory arrest (HCA). This meta-analysis examines the clinical outcomes using colder or warmer circulatory arrest targets with ACP. Methods Electronic searches were performed using four databases from their inception to February 2017. Comparative studies with adult patients who underwent aortic arch surgery using ACP at different circulatory arrest temperatures were included. Data were extracted by two independent researchers and analyzed according to predefined endpoints using a random-effects model. Results Eighteen comparative studies were identified in the literature search, with 1215 patients in the ‘cold’ cohort, and 1417 in the ‘warm’ cohort. Mean HCA temperatures were 20.3°C and 26.5°C in the cold and warm groups. A trend existed for increased permanent neurological deficit overall when colder targets were used (odds ratio [OR] 1.45, 95% confidence interval [CI] 0.98-2.13, p=0.06); this became significant when adjusted estimates were aggregated (OR 1.65, 95% CI 1.06-2.55; p = 0.03). No difference in mortality was seen when adjusted effects were aggregated. Temporary neurological deficit, postoperative dialysis, ventilator time and intensive care unit stay were significantly reduced in the warm cohort overall. No significant differences in re-exploration for bleeding were found. Conclusions ACP with warmer circulatory arrest temperatures may reduce the incidence of permanent neurological deficit, as well as potentially other clinical outcomes. Further studies are required to determine the safe circulatory arrest durations for visceral organs at warmer temperatures.