Growth/differentiation factor 15 promotes EGFR signalling, and regulates proliferation and migration in the hippocampus of neonatal and young adult mice
2014
The activation of epidermal growth factor receptor (EGFR) affects multiple aspects of neural precursor behaviour, including proliferation and migration. Telencephalic precursors acquire EGF responsiveness and upregulate EGFR expression at late stages of development. The events regulating this process and its significance are still unclear. We here show that in the developing and postnatal hippocampus (HP),
growth/differentiation factor(GDF) 15 and EGFR are co-expressed in primitive precursors as well as in more differentiated cells. We also provide evidence that
GDF15promotes responsiveness to EGF and EGFR expression in hippocampal precursors through a mechanism that requires active
CXC chemokine receptor(CXCR) 4. Besides EGFR expression,
GDF15ablation also leads to decreased proliferation and migration. In particular, lack of
GDF15impairs both processes in the cornu ammonis (CA) 1 and only proliferation in the
dentate gyrus(DG). Importantly, migration and proliferation in the mutant HP were altered only perinatally, when EGFR expression was also affected. These data suggest that
GDF15regulates migration and proliferation by promoting EGFR signalling in the perinatal HP and represent a first description of a functional role for
GDF15in the developing telencephalon.
Keywords:
-
Correction
-
Source
-
Cite
-
Save
48
References
29
Citations
NaN
KQI