The Role of Capsule Endoscopy in Celiac Disease

Evaluating patients with suspected celiac disease (CeD) typically includes serologic testing followed by histological confirmation. Given the invasive nature of upper endoscopy, this approach can have limitations. Wireless capsule endoscopy (WCE) allows for noninvasive visualization of the GI tract and is a useful tool for physicians managing patients with suspected or known CeD. In patients unable to undergo upper endoscopy due to medical comorbidities, capsule endoscopy may be utilized to identify mucosal changes consistent with CeD. In patients with nonresponsive celiac disease (NRCD) and refractory CeD (RCD), it is useful for identifying complications such as ulcerative jejunitis and enteropathy-associated T-cell lymphoma (EATL).