Identifying and targeting angiogenesis-related microRNAs in ovarian cancer
2019
Current anti-angiogenic therapy for cancer is based mainly on inhibition of the vascular endothelial growth factor pathway. However, due to the transient and only modest benefit from such therapy, additional approaches are needed. Deregulation of microRNAs (miRNAs) has been demonstrated to be involved in tumor
angiogenesisand offers opportunities for a new therapeutic approach. However, effective miRNA-delivery systems are needed for such approaches to be successful. In this study, miRNA profiling of patient data sets, along with in vitro and in vivo experiments, revealed that miR-204-5p could promote
angiogenesisin
ovarian tumorsthrough THBS1. By binding with
scavenger receptorclass B type 1 (
SCARB1), reconstituted high-density lipoprotein–nanoparticles (rHDL–NPs) were effective in delivering miR-204-5p inhibitor (miR-204-5p-inh) to tumor sites to suppress tumor growth. These results offer a new understanding of miR-204-5p in regulating tumor
angiogenesis.
Keywords:
-
Correction
-
Source
-
Cite
-
Save
54
References
26
Citations
NaN
KQI