P2-310 Gamma-glutamyltransferase as a biomarker for oxidative stress, metabolic syndrome, and alcohol consumption and its association with cancer incidence
2011
Background Alcohol consumption, metabolic factors and oxidative stress have consistently been linked to
cancerdevelopment.
Gamma-glutamyltransferase(GGT) is a biomarker for adverse alcohol consumption and oxidative stress. It is highly related to metabolic factors such as hyperglycaemia, dislipidaemia and obesity. We therefore hypothesise that GGT is associated with
cancerincidence at different sites. Methods First visit measurements in 94 628 adult women and 80 224 men screened for metabolic risk factors as part of the Vorarlberg Health Monitoring & Promotion Programme (VHM&PP). During a median follow-up of 13 years, a total of 5136 incident
cancerswere diagnosed in men and 4665 in women. Sex-specific Cox proportional hazards models, adjusted for age, body-mass index and smoking were performed to estimate HRs and 95% CI per quintiles of GGT. Results In males, there were associations (highest vs lowest quintiles) of GGT with liver
cancer(HR=16.50, 4.00–68.19),
cancersof the lip, oral cavity, pharynx and larynx (HR=3.80, 2.33–6.20), oesophageal
cancer(HR=2.39, 1.01–5.72), pancreatic
cancer(HR=2.13, 1.01–4.56), lung
cancer(HR=2.04, 1.55–2.70), bladder
cancer(HR=1.76, 1.11–2.77),
kidney cancer(HR=1.61, 0.92–2.82, p for trend=0.009) and colorectal
cancer(HR=1.36, 1.01–1.83). In females, the association was most pronounced in cervical
cancer(HR=3.77, 1.94–7.32), followed by lung
cancer(HR=1.63, 1.02–2.60), endometrial
cancer(HR=1.42, 0.98–2.05, p for trend=0.013) and breast
cancer(HR=1.19, 1.02–1.39). Conclusions GGT is a highly promising marker for risk stratification in
cancerprevention.
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