Immunomodulatory Effect of Tonsil-Derived Mesenchymal Stem Cells in a Mouse Model of Allergic Rhinitis:

BackgroundAlthough several studies have claimed that mesenchymal stem cells (MSC) derived from human tissues can ameliorate allergic airway inflammation, the immunomodulatory mechanism of MSCs remains unclear.ObjectiveWe aimed to determine the effects and the underlying mechanism of tonsil-derived MSCs (T-MSC) on allergic inflammationcompared with adipose tissue- derived stemcells (ASC) in a mouse model of allergic rhinitis (AR).MethodsMSCs were isolated from human palatine tonsil(T-MSC) and the surface markers were analyzed. The effect of T-MSCs was evaluated in 24 BALB/c mice that were randomly divided into four groups (negative control group, positive control group, T-MSC group, and ASC group). MSCs were administered intravenously to ovalbumin(OVA) sensitized mice (T-MSC and ASC groups) on days 18 to 23, and subsequent OVA challenge was conducted daily from days 24 to 28. Several parameters of allergic inflammationwere assessed.ResultsT-MSC and ASC had similar characteristics in surface markers. In...