Reduced optimal obstetric and postnatal conditions in children with phenylketonuria and their effect on the success of treatment

: We found a total of 433 reduced obstetric an postnatal conditions in 115 newborns with pku with a range of 0 (n = 4) to -11 (n = 1) per child. The 50th percentile of reduced optimal conditions was at -3, the 90th at -6. Early treated patients with excellent or good dietary control have significantly reduced developmental quotients (DQ) at the age of 3 years when the optimal conditions were reduced above the 90th percentile. Reduced optimal obstetric and postnatal conditions could be found in about 25 per cent of the patients with excellent or good dietary control and a DQ below 100, and in about 50 per cent with a DQ below 85. The effect of treatment is better in patients with excellent and good dietary control and a high value of reduced optimal conditions compared with patients with poor dietary control and an only low value of reduced optimal condition. The quality of dietary control therefore is the most important point to reach an optimal effect in early treated patients.