Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

Aaron Boudreau,Hans E. Purkey,Anna Hitz,Kirk Robarge,David A. Peterson,Sharada Labadie,Mandy Kwong,Rebecca Hong,Min Gao,Christopher Del Nagro,Raju V. Pusapati,Shuguang Ma,Laurent Salphati,Jodie Pang,Aihe Zhou,Tommy Lai,Yingjie Li,Zhongguo Chen,Binqing Wei,Ivana Yen,Steve Sideris,Mark McCleland,Ron Firestein,Laura Corson,Alex Vanderbilt,Simon Williams,Anneleen Daemen,Marcia Belvin,Charles Eigenbrot,Peter K. Jackson,Shiva Malek,Georgia Hatzivassiliou,Deepak Sampath,Marie Evangelista,Thomas OBrien

Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

2016

Aaron Boudreau
Hans E. Purkey
Anna Hitz
Kirk Robarge
David A. Peterson
Sharada Labadie
Mandy Kwong
Rebecca Hong
Min Gao
Christopher Del Nagro
Raju V. Pusapati
Shuguang Ma
Laurent Salphati
Jodie Pang
Aihe Zhou
Tommy Lai
Yingjie Li
Zhongguo Chen
Binqing Wei
Ivana Yen
Steve Sideris
Mark McCleland
Ron Firestein
Laura Corson
Alex Vanderbilt
Simon Williams
Anneleen Daemen
Marcia Belvin
Charles Eigenbrot
Peter K. Jackson
Shiva Malek
Georgia Hatzivassiliou
Deepak Sampath
Marie Evangelista
Thomas OBrien

The application of a potent lactate dehydrogenase(LDHA) inhibitor GNE-140 on pancreatic cancer cells revealed that resistance to GNE-140 is attributable to an AMPK–mTOR–S6K-mediated switch in utilization from glycolysisto oxidative phosphorylation.

Keywords:

Lactate dehydrogenase
Biochemistry
Small molecule
Metabolic pathway
Cell signaling
Pancreatic cancer
Biology
Cell biology
Glycolysis
Oxidative phosphorylation
Cell Plasticity
Cell growth
Programmed cell death

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