Generation of an induced pluripotent stem cell line (FDCHi006-A) from a 7-year-old girl with central precocious puberty.

Abstract Central precocious puberty (CPP) refers to a pediatric endocrine disease in which boys have secondary sexual characteristics before the age of 9 and girls before the age of 8. In this study, we generated an induced pluripotent stem cell line FDCHi006-A from the Peripheral blood cell of a typical central precocious patient who was only 7 years old. This iPSC line showed full pluripotency, normal karyotype and differentiation capacity without integrating vectors. It provides a useful model to study the underlying molecular mechanisms of CPP.