The Role of Epigenetics in Pancreatic Ductal Adenocarcinoma

Epigenetics entails the study of heritable DNA modifications without changes in the nucleotide sequence. This is increasingly understood as a driver in tumor development in various cancers, including pancreatic ductal adenocarcinoma. The changes are reversible and are therefore targets for tumor directed therapies. Further, the cancer specific epigenome can be analyzed through liquid and tissue biopsies, paving the way for diagnostic, screening and prognostic opportunities. In addition, epigenetic changes are influenced by environmental factors and lifestyle, enabling the identification of preventive measures. This chapter explores our current understanding of the epigenome in pancreatic ductal adenocarcinoma and the possibility for epigenetic therapies.