Non-invasive and optimized system for the rejuvenation and removal of wrinkles of the skin

The invention relates to a system and method for the removal of wrinkles and/or provide the rejuvenation of the human skin by use of ultrasound. The method comprises determining a 3D image of a region of the skin using ultrasound, determining a focal depth of the ultrasonic beam for different locations of the skin based on the 3D image, performing the treatment by heating the skin at different locations using an ultrasonic beam, and adjusting the focal depth of the ultrasonic beam according to the determined focal depths during the process of heating the skin at different locations.