S-Adenosylmethionine (SAMe)

Abstract S- adenosylmethionine (SAMe) is an essential biomolecule required for normal cell function and survival. It occurs naturally in the human body and regulates a plethora of cellular functions. This includes the synthesis and metabolism of neurotransmitters and their potential epigenetic effects. Due to the overwhelming encumbrance of depression, the pervasiveness of treatment resistance, and the sizable expense associated with inept remedial treatment for depression compared to successfully treated depression ( Byford et al., 2011 ), there is an immediate desideratum to examine less well recognized pharmacological approaches to treatment. SAMe may be an important addition to the conglomeration of antidepressants. Additionally, it has a crucial physiological role especially in liver function and thus has a potentially therapeutic value in chronic liver diseases. The goal of this chapter is to shed light on the various biochemical processes associated with SAMe and their significance in to human health based on scientific evidence.