Human Herpesvirus 6A U14 Is Important for Virus Maturation
2016
Human herpesvirus 6A (HHV-6A) U14 is a virion protein with little known function in virus propagation. Here, we elucidated its function by constructing and analyzing U14-mutated viruses. We found that U14 is essential for HHV-6A propagation. We then constructed a mutant virus harboring dysfunctional U14. This virus showed severely reduced growth and retarded maturation. Taken together, these data indicate that U14 plays an important role during HHV-6A maturation.
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
36
References
7
Citations
NaN
KQI