A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

Thorlakur Jonsson,Jasvinder Atwal,Stacy Steinberg,Jon Snædal,Palmi V. Jonsson,Sigurbjörn Björnsson,Hreinn Stefansson,Patrick Sulem,Daníel F. Guðbjartsson,Janice Maloney,Kwame Hoyte,Amy Gustafson,Yichin Liu,Yanmei Lu,Tushar Bhangale,Robert R. Graham,Johanna Huttenlocher,Gyda Bjornsdottir,Ole A. Andreassen,Erik G. Jönsson,Aarno Palotie,Timothy W. Behrens,Olafur T. Magnusson,Augustine Kong,Unnur Thorsteinsdottir,Ryan J. Watts,Kari Stefansson

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

2012

A coding mutation in APP, the gene that encodes the amyloid-β precursor protein, is found to protect against Alzheimer’s disease and cognitive decline in the elderly without Alzheimer’s disease.

Keywords:

Age-related cognitive decline
Gene
Disease
Mutation
Cognition
Bioinformatics
Medicine
cognitive decline
Amyloid
Amyloid precursor protein
Allele
Immunology
Dementia

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

1292

Citations