Antithrombotic Treatment after Transcatheter Heart Valves Implant
2018
Transcatheter
heart valve replacementtechnology was introduced as alternative to surgery for the growing high-risk profile population. Developed first,
aortic valve replacement(TAVR) became a standard of care for patients with severe aortic stenosis at high
operative risk, with a potential future use also for low-risk subjects. In the last decade, a multitude of transcatheter
mitral valve replacement(TMVR) devices have been developed for the treatment of severe mitral regurgitation, with encouraging results coming from first-in-man and feasibility studies. As for biological surgical-type valves, transcatheter implanted valves still preserve the risk of thrombosis and embolic events and anticoagulation- or antiplatelet-based strategies are the most widely used options. Unfortunately, these last remain recommended on the basis of empirical or not widely validated evidence. Therefore, given the exponential rise of TAVR and TMVR procedures, it is important to identify the optimal
antithromboticstrategies that best fit the risk of thromboembolic and bleeding events. Hereafter, this review evaluates the current guidelines, trials, and observational data discussing
antithromboticstrategy after transcatheter aortic or
mitral valve replacement.
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