Synthesis of (±)-(Z)-2β-hydroxy-14-hydro-β-santalol employing tandem radical cyclization

Abstract ( Z )-2β-Hydroxy-14-hydro- β-santalol( 1 ), a potent inhibitor of Helicobacter pylorigrowth, was synthesized as a racematevia tandem radical cyclization. Reactivity and stereoselectivity of the cyclization were examined using various substrates, and the bicyclo[2.2.1] heptanestructure was efficiently constructed by a tetheredapproach.