Diverse roles of hepatocyte growth factor activator inhibitor type 1 (HAI-1) in the growth of glioblastoma cells in vivo
2005
Hepatocyte growth factoractivator inhibitor type-1 (
HAI-1) is an integral-membrane proteinase inhibitor. In this study, we examined the effects of
HAI-1 on human
glioblastomacells. Two
glioblastomacell lines (YKG-1, U251) were stably transfected with expression plasmid harboring mature membrane-form or truncated secreted-form
HAI-1. Culture characteristics were not altered by the expression of
HAI-1, whereas in vitro invasiveness of U251 was suppressed. On the other hand, the expression of membrane-form
HAI-1 resulted in significantly enhanced tumorigenicity of both cell lines in vivo. In contrast, secreted-form
HAI-1 did not promote the tumorigenicity. These results suggest that
HAI-1 may play complex roles in progression of
glioblastomacells, and membrane-form
HAI-1 may mediate an undefined important signaling in the cells.
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