Pharmacological restoration of gut barrier function in stressed neonates partially reverses long-term alterations associated with maternal separation

Marion Rincel,Maïwenn Olier,Amandine M. Minni,Camille Monchaux de Oliveira,Yann Matime,Eric Gaultier,Isabelle Grit,Jean-Christophe Helbling,Anna-Maria Costa,Amandine Lépinay,Marie-Pierre Moisan,Sophie Layé,Laurent Ferrier,Patricia Parnet,Vassilia Théodorou,Muriel Darnaudéry

Pharmacological restoration of gut barrier function in stressed neonates partially reverses long-term alterations associated with maternal separation

2019

Marion Rincel
Maïwenn Olier
Amandine M. Minni
Camille Monchaux de Oliveira
Yann Matime
Eric Gaultier
Isabelle Grit
Jean-Christophe Helbling
Anna-Maria Costa
Amandine Lépinay
Marie-Pierre Moisan
Sophie Layé
Laurent Ferrier
Patricia Parnet
Vassilia Théodorou
Muriel Darnaudéry

Rationale Intestinal permeability plays an important role in gut-brain axis communication. Recent studies indicate that intestinal permeability increases in neonate pups during maternal separation (MS).

Keywords:

Blood–brain barrier
Myosin light-chain kinase
Internal medicine
Endocrinology
Barrier function
Intestinal permeability
Psychology
Irritable bowel syndrome
Maternal deprivation
Lachnospiraceae
Corticosterone
Intraperitoneal injection
Gut flora

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