Syntheses of mannopyranoside 6-thiophosphate and 6-deoxy-6-thio-mannopyranoside phosphate as ligands for affinity chromatography

Abstract Direct 6-thiophosphorylation of mannopyranoside gave both the wanted S - as well as the undesired O -phosphates. This required sequential protecting group syntheses to give mannopyranoside6-phosphate and 6-thiophosphate as well as 6-deoxy-6-thio-mannopyranoside6-phosphate, which were transformed into amino-linker compo-nents for affinity chromatography.