Prognostic value of endocapillary hypercellularity in IgA nephropathy patients with no immunosuppression.

Aim Interpretation of retrospective clinicopathological studies of IgA nephropathy (IgAN) has been confoundedby immunosuppressionbias. In published validation studies of the Oxford Classification of IgAN, an average of 33 % of patients received non-randomised steroid and/or cytotoxic therapy. In order to determine the true impact of proliferative lesions on the natural historyof IgAN, analysis of patient cohorts that have received no immunosuppressionis required.