Cross-sectional associations between air pollution and chronic bronchitis: an ESCAPE meta-analysis across five cohorts
2014
Background This study aimed to assess associations of outdoor air pollution on prevalence of chronic
bronchitissymptoms in adults in five cohort studies (Asthma-E3N, ECRHS, NSHD, SALIA, SAPALDIA) participating in the
European Studyof Cohorts for Air Pollution Effects (ESCAPE) project.
MethodsAnnual
averageparticulate matter (PM 10 , PM 2.5 , PM absorbance , PM coarse ), NO 2 , nitrogen oxides (NO x ) and road traffic measures modelled from ESCAPE measurement campaigns 2008–2011 were assigned to home address at most recent assessments (1998–2011). Symptoms examined were chronic
bronchitis(cough and
phlegmfor ≥3 months of the year for ≥2 years),
chronic cough(with/without
phlegm) and chronic
phlegm(with/without cough). Cohort-specific cross-sectional multivariable logistic regression analyses were conducted using common confounder sets (age, sex, smoking, interview season, education), followed by meta-analysis. Results 15 279 and 10 537 participants respectively were included in the main NO 2 and PM analyses at assessments in 1998–2011. Overall, there were no statistically significant associations with any air pollutant or traffic exposure. Sensitivity analyses including in asthmatics only, females only or using back-extrapolated NO 2 and PM 10 for assessments in 1985–2002 (ECRHS, NSHD, SALIA, SAPALDIA) did not alter conclusions. In never-smokers, all associations were positive, but reached statistical significance only for chronic
phlegmwith PM coarse OR 1.31 (1.05 to 1.64) per 5 µg/m 3 increase and PM 10 with similar effect size. Sensitivity analyses of older cohorts showed increased risk of
chronic coughwith PM 2.5abs (
black carbon) exposures. Conclusions Results do not show consistent associations between chronic
bronchitissymptoms and current traffic-related air pollution in adult European populations.
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