Long-term drug survival and clinical effectiveness of etanercept treatment in patients with ankylosing spondylitis in daily clinical practice
2017
OBJECTIVES: Randomised controlled trials and open-label extension studies have demonstrated the clinical efficacy and safety of
tumour necrosis factor-alpha(TNF-α) blocking therapy in pre-selected study patients with ankylosing spondylitis (AS). Our aim was to investigate the 7-year drug survival and clinical effectiveness of
etanercepttreatment in AS patients in daily clinical practice. METHODS: Consecutive AS patients from the prospective observational GLAS cohort who started
etanerceptbecause of active disease were included and evaluated over 7 years according to a fixed protocol. Continuation of treatment was based on
BASDAIimprovement and/or expert opinion. RESULTS: Of the 89 included AS patients, 45 (51%) were still using
etanerceptat 7 years of follow-up. Reasons for treatment discontinuation were adverse events (n=22), inefficacy (n=13), or other reasons although good clinical response (n=9).
Etanercepttreatment resulted in a rapid (after 6 weeks) and sustained improvement in disease activity (
BASDAI, ASDAS, CRP, physician GDA), spinal mobility, physical function (
BASFI), quality of life (ASQoL), and extra-spinal manifestations (swollen joints, tender joints and tender
entheses). Furthermore, concomitant NSAID or DMARD use decreased significantly during follow-up. At 7 years, low disease activity and remission were present in 67-73% and 29-30% of the 45 patients, respectively. Of the patients who discontinued
etanercept, 18 switched successfully to a second or third TNF-α blocker during follow-up. CONCLUSIONS: In a large cohort of AS patients treated with
etanercept, approximately 50% continued this treatment for 7 years. Our broad evaluation of
clinical endpointsproves the long-term effectiveness of
etanercepttreatment in daily clinical practice.
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