Modelling of in vivo LIPUS stimulation of murine intestinal wall

Low Intensity Pulsed Ultrasound could enable a “wireless biopsy” of gut diseases such as ulcerative colitis, by triggering the release of pathology-characterizing molecules from the intestinal wall cells. Prior to the in vivo validation, the prediction of the acoustic propagation through living tissues results fundamental to guide the design of the experimental setting and to be able to reach the target with the desired ultrasound regime. In this work we propose a simulation framework able to precisely predict the ultrasound dose at the target (i.e., mouse colon) for the above-mentioned application.