Hidden Progenitors Replace Microglia in the Adult Brain

degeneration in SBMA? Will ameliorationof the disease by targeting muscleuncover other CNS manifestations?Answering these questions will help intranslating this potential treatment optioninto effective treatment in patients.In summary, the reports by Corteset al. (2014) and Lieberman et al. (2014)emphasize the role of skeletal muscleas an important contributor to SBMApathogenesis and underscore the impor-tance of exploring approaches targetingperipheral tissues for treatment.Clearly, in this disease the musclematters.