The Role of Calcium-Permeable AMPARs in Long-Term Potentiation at Principal Neurons in the Rodent Hippocampus

Long-term potentiation(LTP) at hippocampal CA1 synapsesis classically triggered by the synaptic activation of NMDA receptors(NMDARs). More recently, it has been shown that calcium-permeable (CP) AMPA receptors(AMPARs) can also trigger synaptic plasticityat these synapses. Here we review this literature with a focus on recent evidence that CP-AMPARs are critical for the induction of the PKA- and protein synthesis-dependent component of LTP.