Hemifacial microsomia and abnormal chromosome 22

We report on partial dup(22q), growth deficiency, and the facioauriculovertebral sequence including hemifacial microsomia, cleft lip and palate, preauricular tags, and hearing loss in one patient. No endocrine or systemic cause for growth deficiencywas identified. The case illustrates applicability of chromosome analysisin syndrome-associated growth failure, and a previously unreported associated chromosome abnormality. Am. J. Med. Genet. 76:71–73, 1998. © 1998 Wiley-Liss, Inc.