Porphyrinoid photosensitizers mediated photodynamic inactivation against bacteria
2019
Abstract The multi-drug resistant bacteria have become a serious problem complicating therapies to such a degree that often the term “post-antibiotic era” is applied to describe the situation. The infections with methicillin-resistant S. aureus , vancomycin-resistant E. faecium , third generation
cephalosporin-resistant E. coli , third generation
cephalosporin-resistant K. pneumoniae and
carbapenem-resistant P. aeruginosa have become commonplace. Thus, the new strategies of infection treatment have been searched for, and one of the approaches is based on photodynamic
antimicrobial chemotherapy. Photodynamic protocols require the interaction of
photosensitizer, molecular oxygen and light. The aim of this review is to provide a comprehensive overview of photodynamic
antimicrobial chemotherapyby porphyrinoid
photosensitizers. In the first part of the review information on the mechanism of photodynamic action and the mechanism of the bacteria resistance to the photodynamic technique were described. In the second one, it was described porphyrinoids
photosensitizerslike: porphyrins, chlorins and phthalocyanines useable in photodynamic bacteria inactivation.
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