TNF-α/IL-10 ratio: An independent predictor for coronary artery disease in North Indian population

Abstract Background/Aim Cytokines are responsible for the modulation of immunological and inflammatory processes and play a significant role in the pathogenesis of coronary artery disease ( CAD). Tumor necrosis factor-alpha (TNF-α) are considered as a pro inflammatory and interleukin-10(IL-10) anti inflammatory have been shown to predict the risk of incident of CAD. Aim of present study is to examine the impact of the TNF-α and Il-10 levels on various components of the CAD. Methods Total 580 subjects were recruited in the present study out of which 290 diagnosed CADsubjects (Age 51.61 ± 9.26; BMI 25.27 ± 3.58) and 290 healthy controls (Age 51.72 ± 9.48; BMI 24.02 ± 7.42). Serum TNF-alpha and IL-10 levels were measured by ELISA. Results Data of present study revealed that CADpatients had higher frequency (p = 0.001) of smoking (38.28%), Alcohol (21.03%), Diabetes (53.45%) and hypertension (48.28%) as compare to controls. Moreover, we have observed highly significant (p Conclusion The findings of present study suggest that the TNF-α/IL-10 ratio may play a vital role in the development of CADof North Indian population.