Case report: de novo ANCA-associated vasculitis after kidney transplantation treated with rituximab and plasma exchange
2018
Anti-neutrophil cytoplasmic antibody(ANCA)-associated
vasculitiscauses end-stage renal failure in up to a third of cases even with treatment. The disease recurs occasionally after kidney transplantation, but new onset of ANCA-associated
vasculitisafter transplantation is highly unusual. The use of rituximab or
plasmapheresisfor de novo disease after transplantation has not previously been reported. Routine post-transplant follow-up for a 66-year old asymptomatic woman revealed a rise in creatinine from 1.8 to 2.6 mg/dl and increased proteinuria. She had received a cadaveric kidney transplant 20 months previously for end-stage
autosomal dominant polycystic kidney disease. Renal allograft biopsy unexpectedly demonstrated
pauci-immune
glomerulonephritiswith extracapillary proliferation and interstitial inflammation. Concurrent serum tested strongly positive for ANCA specific to
proteinase 3(PR3), but stored pre- and post-transplantation serum samples tested negative. These findings established a diagnosis of de novo ANCA-associated
vasculitisin the renal allograft. We started treatment with high-dose corticosteroid and rituximab. Despite this, serum creatinine continued to rise and
glomerulonephritisremained active in a repeat biopsy. Escalation of the treatment with seven sessions of
plasmapheresisled to a temporary improvement in creatinine. No further features of
vasculitisemerged and PR3-ANCA titres declined. However, multiple infections complicated the recovery period and were associated with progressive loss of renal transplant function. Four months after the index presentation, transplant function became insufficient and dialysis was restarted. De novo ANCA-associated
vasculitisafter renal transplantation is exceptionally rare. It poses a significant risk to graft survival even in the context of intensified immunosuppression. Management relies on clinical evidence from populations with native renal function, yet post-transplant patients may be at increased risk of treatment-related adverse events. Precautions against these risks are crucial in the delivery of care.
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