Clonal evolution of chronic lymphocytic leukemia to Langerhans cell histiocytosis: a case report
2019
The traditional concept of unidirectional maturation of hematopoietic cells has been called into question due to the recognition of lineage plasticity, which is increasingly found also in the clonal evolution of hematopoietic and lymphoid malignancies. Here we present an unusual case of a patient with TP53-mutated
chronic lymphocytic leukemia(CLL) treated with a PI3Kδ inhibitor evolving to clonally related
Langerhans cell histiocytosis(LCH) with acquired BRAF
V600Eand
STK11mutations and loss of expression of PAX-5 and other examined B cell markers. In indolent
B cell lymphoma, transformation to a more aggressive
high-grade lymphomaoccurs frequently during the course of disease and is thought to be caused by clonal evolution. Our case further supports the concept of significant lineage plasticity in lymphomas and raises the question of a potential role of novel pharmacologic agents in clonal evolution.
Keywords:
-
Correction
-
Source
-
Cite
-
Save
14
References
2
Citations
NaN
KQI