Study on the correlation of parathyroid hormone and osteocalcin in hemodialysis patients

Objective To explore the clinical value and the correlation of parathyroid hormone and osteocalcin in hemodialysis patients. Methods According to the dialysis duration of hemodialysis patients, they are divided into the four groups, Ⅰ(dialysis time 5 - 10 years), Ⅳ(dialysis time> 10 years),50 cases were randomly selected from each group,50 cases of healthy people were taken as a control group, to detect the contents of PTH and N- MID in serum and analyze the results. Results The content of PTH in hemodialysis patients of I,II,III,IV group were(170.9±45.9)ng/L, (405.4±65.3)ng/L,(717.1±199.6)ng/L,(1 555.6±417.8)ng/L, the content of N- MID were(79.23±31.62)μg/ L,(140.22±50.98)μg/L,(496.11±159.49)μg/L,(617.9±386.18)μg/L,the content of PTH and N- MID in control group were(6.85±3.74)ng/L,(16.6±8.57)μg/L,PTH and N- MID levels of the four hemodialysis patients groups were significantly higher than those of normal control group,the differences had statistically significance(PTH levels of the four groups compared with the control group:groupⅠcompared with the control group,t= 25.199,P< 0.01;groupⅡcompared with the control group,t= 43.091,P< 0.01;groupⅢcompared with the control group,t= 25.402,P< 0.01;groupⅣcompared with the control group,t= 26.211,P< 0.01;N- MID levels of the four groups compared with the control group:groupⅠcompared with the control group,t= 13.518,P<0.01;group Ⅱ compared with the control group,t= 16.909,P< 0.01;group Ⅲ compared with the control group,t= 21.229,P< 0.01;group Ⅳ compared with the control group,t= 11.007,P< 0.01),the content of PTH and N- MID in I,II,III,IV groups had statistically significance(four groups of PTH levels compare to each other:groupⅠcompared with groupⅡ,t= 20.774,P < 0.01;groupⅠcompared with groupⅢ,t= 18.858,P< 0.01;groupⅠcompared with groupⅣ,t= 23.295,P <0.01;group Ⅱ compared with group Ⅲ,t= 10.495,P<0.01;groupⅡcompared with group Ⅳ,t= 19.233,P < 0.01;group Ⅲ compared with group Ⅳ,t= 12.805,P< 0.01;Four groups of N- MID levels compare to each other:group Ⅰ compared with group Ⅱ,t= 7.189,P<0.01;group Ⅰ compared with group Ⅲ,t= 18.130,P< 0.01;group Ⅰ compared with group Ⅳ,t= 9.830,P< 0.01;group Ⅱ compared with group Ⅲ,t= 15.029,P< 0.01;group Ⅱ compared with group Ⅳ,t= 8.671,P< 0.01;group Ⅲ compared with group Ⅳ,t= 2.061,P< 0.05). Conclusion PTH levels were positively correlated with N-MID content in hemodialysis patients, high PTH hemodialysis patients should prevent osteoporosis early and to take appropriate treatment. Key words: Hemodialysis; Parathyroid hormone; Osteodystrophy; Osteoporosis