Manganese-Catalyzed [4 + 2] Annulation of N-H Amidines with Vinylene Carbonate via C-H Activation.

Manganese-catalyzed C-H bond functionalization of aryl amidines for the synthesis of 1-aminoisoquinolines in the presence of vinylene carbonate has been developed. The reaction features a broad substrate scope and proceeds under mild reaction conditions with only the carbonate anion as the byproduct.