HiVA: an integrative wet- and dry-lab platform for haplotype and copy number analysis of single-cell genomes

Haplotypingis imperative for comprehensive analysis of genomes, imputation of genetic variants and interpretation of error-prone single-cell genomicdata. Here we present a novel sequencing-based approach for whole- genomeSNP typing of single cells, and determine genome-wide haplotypes, the copy number of those haplotypesas well as the parental and segregational origin of chromosomal aberrations from sequencing- and array-based SNP landscapes of single cells. The analytical workflow is made available as an interactive web application HiVA (https://hiva.esat.kuleuven.be).