Ocular adnexal lymphoma and Helicobacter pylori gastric infection
2010
There is a causal association between Helicobacter pylori (Hp) gastric infection and the development of gastric
MALT lymphoma. In contrast, the link between Hp gastric infection and the development of extragastric
lymphomahas not been thoroughly investigated. We, therefore, studied the prevalence of gastric Hp infection at initial diagnosis of ophthalmologic and nonophthalmologic extragastric
lymphomapatients. Three cohorts of patients were studied: a first one of 83 patients with OAL, a second one of 101 patients with extraophthalmologic extragastric
lymphoma, and a third one of 156 control individuals (control) without malignant
lymphoma. Gastric Hp infection was investigated by histopathological analysis and Hp-specific PCR assay on
gastric biopsytissue samples. We found gastric Hp infection in 37 OAL patients (45%), in 25 extraophthalmologic extragastric
lymphomacases (25%), and in 18 controls individuals (12%) (P < 0.0001 OAL/C and P < 0.01 OAL/extra-OAL cases). Gastritis was found in 51% and 9% of Hp-positive and Hp-negative
lymphomapatients, respectively (P < 10−4). Gastric Hp infection only correlated with MALT/LPL
lymphoma(P = 0.03). There is a significant association between gastric Hp infection and MALT/LPL OAL. This suggests a novel mechanism of indirect infection-associated lymphomagenesis whereby chronic local antigen stimulation would lead to the emergence of ectopic B-cell
lymphoma. © 2010 Wiley-Liss, Inc. Am. J. Hematol.
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