Gene expression profiling of 49 human tumor xenografts from in vitro culture through multiple in vivo passages - strategies for data mining in support of therapeutic studies

Melinda G. Hollingshead,Luke H. Stockwin,Sergio Y. Alcoser,Dianne L. Newton,Benjamin Orsburn,Carrie Bonomi,Suzanne D Borgel,Raymond Divelbiss,Kelly Dougherty,Elizabeth J Hager,Susan Holbeck,Gurmeet Kaur,David J Kimmel,Mark W Kunkel,Angelena Millione,Michael Mullendore,Howard Stotler,Jerry M. Collins

Gene expression profiling of 49 human tumor xenografts from in vitro culture through multiple in vivo passages - strategies for data mining in support of therapeutic studies

2014

Melinda G. Hollingshead
Luke H. Stockwin
Sergio Y. Alcoser
Dianne L. Newton
Benjamin Orsburn
Carrie Bonomi
Suzanne D Borgel
Raymond Divelbiss
Kelly Dougherty
Elizabeth J Hager
Susan Holbeck
Gurmeet Kaur
David J Kimmel
Mark W Kunkel
Angelena Millione
Michael Mullendore
Howard Stotler
Jerry M. Collins

Background Development of cancer therapeutics partially depends upon selection of appropriate animal models. Therefore, improvements to model selection are beneficial.

Keywords:

Gene expression profiling
DNA microarray
Regulation of gene expression
Cancer
Genetics
In vivo
Bioinformatics
In vitro
Biology
Proteomics
human tumor

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