The PUF Protein Family: Overview on PUF RNA Targets, Biological Functions, and Post Transcriptional Regulation
2018
Post-transcriptional regulationof
gene expressionplays a crucial role in many processes. In cells, it is mediated by diverse
RNA-binding proteins. These proteins can influence mRNA stability, translation, and localization. The PUF
protein family(Pumilio and FBF) is composed of
RNA-binding proteinshighly conserved among most eukaryotic organisms. Previous investigations indicated that they could be involved in many processes by binding corresponding motifs in the 3′UTR or by interacting with other proteins. To date, most of the investigations on PUF proteins have been focused on
Caenorhabditis elegans,
Drosophila melanogaster, and
Saccharomyces cerevisiae, while only a few have been conducted on
Arabidopsis thaliana. The present article provides an overview of the PUF
protein family. It addresses their RNA-binding motifs, biological functions, and post-transcriptional control mechanisms in
Caenorhabditis elegans,
Drosophila melanogaster,
Saccharomyces cerevisiae, and
Arabidopsis thaliana. These items of knowledge open onto new investigations into the relevance of PUF proteins in specific plant developmental processes.
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