Intracellularly expressed nanobodies against non-structural protein 4 of porcine reproductive and respiratory syndrome virus inhibit virus replication.

Hongliang Liu,Chao Liang,Hong Duan,Xiaobin Zhang,Xiangpeng Wang,Shuqi Xiao,En-Min Zhou

Intracellularly expressed nanobodies against non-structural protein 4 of porcine reproductive and respiratory syndrome virus inhibit virus replication.

2016

Hongliang Liu
Chao Liang
Hong Duan
Xiaobin Zhang
Xiangpeng Wang
Shuqi Xiao
En-Min Zhou

Objective To isolate specific nanobodies to porcine reproductive and respiratory syndrome virus (PRRSV) non-structural protein 4 (Nsp4) and investigate their potential antiviral activities.

Keywords:

Porcine reproductive and respiratory syndrome virus
Biology
Molecular biology
Viral replication
Single-domain antibody
Intrabody
Virology
Lentivirus
structural protein
Cell culture

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